Wednesday, December 31, 2014
Monday, December 29, 2014
Top 10 posts of 2014: # 2 Test Your Knowledge: Hemodialysis http://t.co/C8DJSa2uVz— Dr. Matt Sparks (@eAJKD) December 31, 2014
Top 10 posts of 2014: # 3 Drug Abusers and Kidney Disease: A Pathologist Perspective http://t.co/bq35BNzSBt— Dr. Matt Sparks (@eAJKD) December 30, 2014
Top 10 posts of 2014: # 4 Test Your Knowledge: Acid-Base Disturbances in the Hemodialysis Patient http://t.co/YcdaWQixag
— Dr. Matt Sparks (@eAJKD) December 29, 2014
Top 10 posts of 2014: # 5 Lupus Nephritis: A 2014 Treatment Update http://t.co/w3T1zInJCn— Dr. Matt Sparks (@eAJKD) December 28, 2014
Top 10 posts of 2014: # 7 A 2014 Update on Glomerular Diseases http://t.co/881EdjFHnJ— Dr. Matt Sparks (@eAJKD) December 26, 2014
Top 10 posts of 2014: # 10 Kidney Week 2014: New Drug for Hyperkalemia http://t.co/vgQH8ETZ0A— Dr. Matt Sparks (@eAJKD) December 23, 2014
Wednesday, December 24, 2014
Hilarious Research Ethics Board(REB) - A Christmas Ethics Approval Letter - Have a Merry Christmas!!
Dr. K. Kringle,
Adjunct Professor of Child Psychology
Far Northern University
Dear Dr. Kringle:
At the regularly scheduled December 19 meeting, the REB reviewed your protocol, "A Global Observational Study of Behavior in Children." While we believe it has many good features, it could not be approved as submitted. Kindly modify your study to address the following concerns:
1. You propose to study "children of all ages". Please provide an exact lower and upper age limit, as well as the precise number of subjects. Provide a statistically valid power calculation to justify this large a study.
2. You propose to "know when they are sleeping and know when they are awake". How will this be done? Will children undergo video monitoring in their beds? Will they have sleep EEGs? You list 100 elves as research assistants. Are any of them sleep physiologists? Are you proposing covert surveillance of your subjects? Is there any risk that children who do not believe in Santa Claus will also be video-recorded?
3. Your primary outcome measure is to "know when they've been bad or good." What standard is being used to determine 'goodness'? Do children have to be good all year or just most of the time? What if they have been really, really, good except for one time when they hit their little brother?
4. You state that compensation for participation will be "sugarplums, candy, and toys" for the good little girls and boys. This may not be appropriate for the children with obesity, dental caries, and hyperactivity. Also, your proposal to leave a lump of coal in the stockings of the bad children will be unfairly stigmatizing to them individually and as a group. In general, the Board suggests a small token of appreciation for all participants. Perhaps a $5 Toys-R-Us gift card would be better.
5. The database of good and bad children will be kept "on a scroll at the North Pole." Please describe the security provisions you have in place to protect the research data. Is the scroll kept in a locked cabinet in a locked room? Who has access to the scroll? Are there backup copies of the scroll and how often are they compared to the original? What plans are there for long-term disposition of the scroll.
6. You mention the participation of "eight tiny reindeer" in your protocol. Please provide the Board with file number of your approved animal use protocol.
7. Please provide evidence of Part 1 animal user training and Part 2 Reindeer training for yourself and for anyone else involved in the care and handling of the reindeer. As well, attach your SOPS for animal husbandry and monitoring.
Please submit these changes and additional documentation by modified your online submission and responding to the reviewer notes. If you require assistance with REMO, please contact the Research Ethics Office or the committee coordinator.
Please note that the office will be closed from December 25 to January 1 inclusive.
Once your changes are approved, you will be able to conduct your study sometime in January.
E Scrooge, PhD, MD — Chair, Research Ethics Board
cc A Grinch – Chair, Animal Care and Use Committee
Time-dependent variability in tacrolimus trough levels is a risk factor for kidney transplant failure http://t.co/kF1QefwcS9— Richard McCrory (@iamdoctord) June 9, 2014
Most Popular: OSAKA Trial: A Randomized, Controlled Trial Comparing Tacrolimus QD and BD in Kidney Transplant... http://t.co/T3VizMrwck— Transplantation (@TransplantJrnl) November 20, 2013
Sunday, December 21, 2014
Tuesday, December 16, 2014
Sunday, December 14, 2014
Urinary diversion. - PubMed - NCBI http://t.co/PCyxPjmPVC A good review from Urology 2007 WHO Consensus Conference. Types and Complications— Nikhil Shah (@dr_nikhilshah) December 14, 2014
Friday, December 12, 2014
Systematic review and meta-analysis on management of hemodialysis catheter-related bacteremia | Read by QxMD
Wednesday, December 10, 2014
Joint UK societies' 2014 consensus statement on renal denervation for resistant hypertension - http://t.co/WmPvndA9Ds— Renal Association (@RenalAssoc) December 10, 2014
Moving onto next level.Tweetbook's real purpose - classifying tweets into meaningful PAGES collection. http://t.co/CRma4AIc48 Suggestions?— Nikhil Shah (@dr_nikhilshah) December 10, 2014
Tuesday, December 9, 2014
Monday, December 8, 2014
Sunday, December 7, 2014
@NephJC: @dr_nikhilshah You've been quoted in my #Storify story "Hyperkalemia: Causes and Treatments part 1" sfy.co/d02tq -- shared via UberSocial http://ubersocial.com
@NephJC: @dr_nikhilshah @nephondemand You've been quoted in my #Storify story "Hyperkalemia: Causes and Treatments part 2" sfy.co/h04A7 -- shared via UberSocial http://ubersocial.com
Thursday, December 4, 2014
@ASPNeph: Better understanding of transplant glomerulopathy secondary to chronic antibody-mediated rejection http://m.ndt.oxfordjournals.org/content/early/2014/12/03/ndt.gfu371 -- shared via UberSocial http://ubersocial.com
Wednesday, December 3, 2014
Buttonhole versus rope-ladder cannulation of arteriovenous fistulas for hemodialysis: a systematic review.
BACKGROUND:The buttonhole technique is an alternative method of cannulating the arteriovenous fistula (AVF) in hemodialysis (HD), frequently used for home HD patients. However, the balance of risks and benefits of the buttonhole compared with the rope-ladder technique is uncertain.
STUDY DESIGN:A systematic review of randomized trials and observational studies (case reports, case series, studies without a control group, non-English studies, and abstracts were excluded).
SETTING & POPULATION:HD patients (both in-center conventional HD and home HD) using an AVF for vascular access.
SELECTION CRITERIA FOR STUDIES:We searched MEDLINE, EMBASE, EBM Reviews, and CINAHL from the earliest date in the databases to March 2014 for studies comparing clinical outcomes of the buttonhole versus rope-ladder technique.
INTERVENTION:Buttonhole versus rope-ladder cannulation technique.
OUTCOMES:The primary outcomes of interest were patient-reported cannulation pain and rates of AVF-related local and systemic infections. Secondary outcomes included access survival, intervention, hospitalization, and mortality, as well as hematoma and aneurysm formation, time to hemostasis, and all-cause hospitalization and mortality.
RESULTS:Of 1,044 identified citations, 23 studies were selected for inclusion. There was equivocal evidence with respect to cannulation pain: pooled observational studies yielded a statistical reduction in pain with buttonhole cannulation (standardized mean difference, -0.76 [95%CI, -1.38 to -0.15] standard deviations), but no difference in cannulation pain was found among randomized controlled trials (standardized mean difference, 0.34 [95%CI, -0.76 to 1.43] standard deviations). Buttonhole, as compared to rope-ladder, technique appeared to be associated with increased risk of local and systemic infections.
LIMITATIONS:Overall poor quality and substantial heterogeneity among studies precluded pooling of most outcomes.
CONCLUSIONS:Evidence does not support the preferential use of buttonhole over rope-ladder cannulation in either facility-based conventional HD or home HD. This does not preclude buttonhole cannulation as being appropriate for some patients with difficult-to-access AVFs.
Copyright © 2014 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
KEYWORDS:Buttonhole; access-related infection; arteriovenous fistula (AVF); cannulation technique; chronic kidney disease (CKD); end-stage renal disease (ESRD); hemodialysis (HD); needling pain; rope-ladder; systematic review; vascular access
Tuesday, December 2, 2014
Nephrology Tweetbook (social-kidney.blogspot.ca)